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Conservation of BRCA1Committee Members:Anne Haake, Ph.DDina Newman, Ph.D Maureen Ferran, Ph.D Gary Skuse, Ph.D AbstractMost research has been conducted on the structure and function of many individual genes as well as complementary proteins. Many of these studies look at specific population group's country of origin, geographic location, or ethnicity but do not correlate findings between these groups. In this project I attempted to associate the structural and functional consequences of individual mutations in Human BRCA1 to other organisms. My findings suggest a strong correlation between human geographic isolation and mutation exclusivity. Furthermore strong sequence and mutation conservation as well as structural homology exist between many species.Conservation of BRCA1 RIT Bioinformatics |
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